Henry et al described that elevated LDH was associated with more than 6 fold increase in odds of severe disease and more than 16 fold increase in odds of mortality [10]. the Mmp15 disease Nandrolone process, the knowledge of which is helpful in early diagnosis and management of these patients. An extensive immune profiling of B and T cell population with analysis of spectrum of immune changes during the period of contamination were also discussed. In COVID-19, changes in laboratory parameters and hematologic abnormalities have been reported and its association with early diagnosis, disease prognosis and severity has been repeatedly discussed in the literature. Changes in laboratory investigations help in risk stratification and early intervention. The most common laboratory obtaining in COVID-19 is usually lymphopenia. COVID-19 patients presented with coagulopathy is at high risk of morbidity and mortality. In severe COVID-19 patients, bone marrow aspirate shows histiocytic proliferation with hemophagocytosis. To understand the correlations between immune responses and severity of COVID-19, immune profiling of B and T cell population was compared with extensive clinical data. A deep understanding of the laboratory findings and haematological abnormalities associated with SARS-CoV-2 contamination would help to raise disease suspicion in absence of Real time polymerase chain reaction or antibody results. Also the blood counts along with the morphological changes in peripheral blood would be helpful in prompt screening, diagnosis, prognosis and management of COVID-19 patients. 31%) for patients with COVID-19 and they were 6 times more likely to die within 48 hours than the patients with normal RDW at the time of admission. Along with that they suggested that during hospitalisation, an increasing RDW was associated with increased risk of mortality ( 0.5% increase in RDW increase mortality rate from 6% to 24%) [51]. Other studies also indicate RDW as marker of complication in COVID-19. In COVID-19, anaemia is an impartial predictor of poor outcome as in several other respiratory diseases. The median haemoglobin level was lower in severe cases than in non-severe cases [40]. Lymphopenia in COVID-19, seems to be the most relevant severity biomarker of the contamination [52]. The definition of lymphopenia is different in different studies, however lymphocyte count 1100 L in few studies showed consistent results. Huang et al [53] and Wang et al [54] found that there was an association between lymphopenia and need of ICU care. Wu et al [55] showed an association between lymphopenia and acute ARDS development. Increased total leucocyte count and absolute neutrophil count were high risk factors for severe Nandrolone COVID-19 and were associated with increased risk of death [55]. NLR and platelet/lymphocyte ratio (PLR) at peak platelets have prognostic value in determining severe cases [56]. Fan et al [21] found that patient requiring ICU care had lymphopenia, neutrophila, high LDH and were of older age. A decreased lymphocyte/leukocyte count ratio has been reported indicating severe disease and/or fatal outcomes [57]. Study also suggested that increased neutrophil/lymphocyte and neutrophil/platelets ratio may be indicative of myocardial injury and increased mortality [20,58]. Pakos et also stated that a higher rate of death mortality is usually associated with lower absolute monocyte count and higher NLR [40]. In addition to the NLR, NCD4LR is usually associated with a longer virus negative conversion time and with a prolonged virus clearance and worse immune function [28]. The LMR value may also be considered a clinical marker to show the severity of the disease. Another biomarker, the neutrophil count to albumin ratio, has also been described as a predictor of mortality in COVID-19 patients [29]. Studies suggested that thrombocytopenia is usually significantly associated with increased risk Nandrolone of severe disease, need for ICU care and mortality in COVID-19 [59]. Inflammatory indices, including increased ESR, CRP, LDH ( 250 U/L) and IL-6 can also use as predictor for dismal prognosis. Increased LDH may reflect multiple organ injury and is also associated with higher risk of acute respiratory distress syndrome, need of ICU care and mortality [10,11,13]. Henry et al described that elevated LDH was associated with more than 6 fold increase in odds of severe disease and more than 16 fold increase in odds of mortality [10]. In COVID-19 a high CRP level ( 10 mg/Liter) is usually associated with unfavourable aspects, such as development of ARDS, higher Troponin-T levels, myocardial injury and death [5,55,56,59]. COVID-19 patients with elevated bilirubin are associated with worse prognoses and severe disease [15]. High serum ferritin levels is usually associated with increased death as suggested by Zhou et al. [18]. Increased levels of IL-6 and LDH have been associated with increased risk of death [55]. In COVID-19, high procalcitonin level can also be used as predictor of patients at high risk for.