Lisa Topolnik, PhD

Lisa is our scientific leader and the soul of the laboratory. She holds a faculty position in Biophotonics at the Department of Biochemistry, Microbiology and Bioinformatics at Université Laval.

She graduated from the Odessa National University in the field of Human and Animal Physiology and received her PhD in the field of Neurobiology from the Bogomoletz Institute of Physiology (2000) in Ukraine.

She then moved to Canada to pursue postdoctoral training, first, with the group of Dr. Mircea Steriade at Université Laval and, second, with Dr. Jean-Claude Lacaille at Université de Montréal. In 2007, she moved back to Université Laval and received the University Faculty Award for Women from Natural Sciences and Engineering Research Council of Canada to develop her research program.



Sarah Côté, Lab technician

Sarah is in charge of mouse colonies, as well as basic molecular biology and immunohistochemistry techniques.



Vincent Villette, postdoc

Using in vivo two-photon Ca-imaging of hippocampal interneurons in head-restrained behaving mice, Vincent explores the mechanisms of cell-specific recruitment during epilepsy and AD.



Einer Munoz, PhD student

Einer is in the lab since September 2014. Using a combination of patch-clamp recordings and neuroanatomy, he is investigating the physiological features of specific types of interneurons and the role of gap junctions.



Xiao Luo, PhD Student

Xiao joined the lab in January 2014. He is using a combination of patch-clamp electrophysiology & optogenetics to target specific glutamatergic inputs to hippocampal interneurons.



Ruggiero Francavilla, PhD student

Ruggiero Francavilla is using patch-clamp electrophysiology, neuroanatomy, behavioural analysis and imaging in vivo to explore VIP-interneurons in the hippocampus during aging and AD.



Olivier Camiré, PhD student

Olivier joined our lab in September 2010, first, as an undergraduate and then as a master student. His research project is to investigate the calcium fluctuations in dendrites of hippocampal interneurons. He becomes an expert in two-photon Ca2+ imaging in combination with patch clamp recordings in hippocampal slices in vitro.



Linda David, postdoc (2013-2015)
Current position: postdoc, CRCHUQ-UL, Québec (Canada)

Elise Magnin, MSc student (2011-2014)
Current position: student in scientific journalism, Université de Bordeaux (France)

Leonid Tyan, Postdoc (2012-2014)
Current position: Postdoc (University of Wisconsin-Madison, USA)

Simon Chamberland, MSc student (2009-2013)
Current position: PhD student, CRIUSMQ, Québec (Canada)

Charleen Salesse, MSc student (2008-2012)
Current position: PhD student, CRIUSMQ, Québec (Canada)

Alesya Evstratova, PhD student (2008-2010)
Current position: potsdoc, CRIUSMQ, Québec (Canada)

Recent Publications

Francavilla R, Luo X, Magnin E, Tyan L,
Topolnik L. (2015)
Coordination of dendritic inhibition through local disinhibitory circuits.
Frontiers in Synaptic Neuroscience 2015 Feb 26;7:5.
doi: 10.3389/fnsyn.

Tyan L, Chamberland S, Magnin E, Camiré O, Francavilla R, David LS, Deisseroth K,
Topolnik L. (2014)
Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry.
J Neurosci. Mar 26;34(13):4534-47.
doi: 10.1523/JNEUROSCI.

Camiré O,
Topolnik L. (2014)
Dendritic calcium nonlinearities switch the direction of synaptic plasticity in fast-spiking interneurons.
J Neurosci. Mar 12;34(11):3864-77
doi: 10.1523/JNEUROSCI.

Chamberland S,
Topolnik L. (2012)
Inhibitory control of hippocampal inhibitory neurons.
Front Neurosci. 2012;6:165. doi: 10.3389/fnins.
Epub 2012 Nov 14.

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